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Khabre desk
Recent reporting, analysis and explainers from the Alzheimer’s disease desk.
science
A bioRxiv preprint presents a 658,059-cell reference atlas of human hippocampus development and uses it to study brain organoids carrying the familial Alzheimer’s disease-associated PSEN1 E280A variant. The organoids showed altered cell composition, gene expression and inferred neuronal maturation.
science
A Nature Review proposes that Alzheimer’s disease develops through discrete molecular, cellular and network transitions rather than a single linear cascade from amyloid-β to Tau pathology and neurodegeneration. The framework places amyloid-associated Tau phosphorylation at a pivotal biological threshold.
health
A medRxiv preprint reports that laromestrocel reduced measures of brain inflammation and atrophy in 49 people with mild Alzheimer’s disease. The findings come from an early clinical study and have not yet been published as a peer-reviewed journal article.
science
Researchers mapped 4,321 microproteins in 608 post-mortem human brain samples, including dozens with altered expression in Alzheimer’s disease. The atlas expands the molecular inventory available for studying neurodegeneration, while the proteins’ biological roles still require experimental validation.
health
A longitudinal study of 3,119 older adults found that Alzheimer’s disease dementia risk was associated independently with pathological burden and cognitive resilience. The two factors also interacted, with the highest risk among people with high pathology and low resilience.