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Menopause Therapy’s Brain Associations Vary by Formulation and APOE ε4
A medRxiv preprint analysing 8,741 female participants older than 70 reports that associations between menopause hormone therapy, cognition and brain structure differed by treatment formulation and APOE ε4 status. Among APOE ε4 carriers, estradiol-based therapy was linked to more favourable cognitive and imaging measures than conjugated equine estrogens.