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Airway model shows antibiotics can favour less damaging Pseudomonas infections

In a preprint, researchers report that antibiotic selection on human airway tissue favoured Pseudomonas aeruginosa clones that preserved the tissue and survived treatment better. The finding suggests that standard susceptibility measurements can miss infection traits shaped by the host environment.

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DNA repeat changes can alter drug susceptibility in Mycobacterium tuberculosis

A bioRxiv preprint reports that insertions and deletions in several classes of repeated DNA sequences can change antibiotic susceptibility in Mycobacterium tuberculosis. Laboratory reconstruction identified a ppe53 repeat deletion that produced intermediate resistance to isoniazid, rifampicin and streptomycin.