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Khabre desk
Recent reporting, analysis and explainers from the antibodies desk.
health
A bioRxiv preprint reports that mutations tuning complement activity changed how selected monoclonal antibodies protected neonatal mice from lethal HSV-1 infection. The effects varied with the antibody and its viral target.
health
A bioRxiv preprint reports that antibodies targeting the HCMV gH/UL116 envelope complex can neutralize the virus or activate Fcγ receptors, depending on where they bind. Immunization with the complex also elicited antibody responses in mice linked to both activities.
health
A bioRxiv preprint describes two patient-derived anti-HPA-1a antibodies and finds that one induced platelet aggregation through coordinated binding to HPA-1a and FcγRIIa. The laboratory study provides a mechanistic explanation for functional differences among antibodies involved in fetal and neonatal alloimmune thrombocytopenia.