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Khabre desk
Recent reporting, analysis and explainers from the antibody engineering desk.
science
A bioRxiv preprint describes BiAb J31, an IgG-like bispecific antibody that links TNF-α to the endocytic receptor ASGPR1. In HepG2 cell experiments, the antibody recruited TNF-α-containing complexes and promoted their uptake.
science
A bioRxiv preprint presents ForceFlowAb, a mixture-of-experts flow-matching model that designs antibody CDR sequences and structures with force-field guidance. The authors report more favourable antibody–antigen interaction-energy results than two comparison methods in CDR-H3 and six-CDR design tasks.