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Khabre desk
Recent reporting, analysis and explainers from the antimicrobial-resistance desk.
health
A medRxiv preprint reports that NG-TEST Acineto-5 detected all targeted carbapenemases in a 433-isolate evaluation, with no false positives among isolates lacking them. Four of five Acinetobacter radioresistens isolates carrying an intrinsic OXA-23-like gene produced weak positive signals.
health
A bioRxiv preprint reports that the bacterial enzyme LysM can kill several Gram-negative hospital pathogens and disrupt their biofilms, particularly when combined with EDTA. Tests included laboratory experiments and a human airway organoid model, not treatment in patients.
science
A bioRxiv preprint reports that simulated mixtures of E. coli strains made sequence-type and serotype prediction less reliable than detection of individual resistance and virulence genes. Increasing the dominant strain’s abundance improved strain-level predictions, while longer reads alone did not resolve the challenge.
health
A bioRxiv preprint reports that bacteria sampled from chronic Pseudomonas aeruginosa lung infections in people with cystic fibrosis differed in susceptibility to some bacteriophages. The findings point to variation in bacterial cell-surface features as one possible reason and highlight a challenge for phage therapy.
science
A bioRxiv preprint describes TriComm, a three-strain microbial community maintained in continuous culture to study plasmid-mediated antimicrobial resistance. The authors report that resistance plasmids protected the community from collapse under antimicrobial treatment, with protection depending on plasmid transfer.
health
A bioRxiv preprint analysing 1,501 publicly available Enterobacterales genomes found 241 combinations of genes from five carbapenemase families. It also reports that cross-family combinations increased over time in the dataset.
health
A prospective observational study at two tertiary-care hospitals found that broad whole-genome sequencing detected many Gram-negative genomic clusters involving patients without multidrug-resistant isolates or intensive-care exposure. The medRxiv preprint also found that detection increased with sequencing effort and that blood-culture-only surveillance would have identified very few clustered patients.