science
Haemprotein catalysis makes chiral oxazolidinones from unactivated alkenes
A peer-reviewed Nature study reports a haemprotein-catalysed reaction sequence that makes chiral oxazolidinones directly from unactivated alkenes.
Khabre desk
biocatalysis
Recent reporting, analysis and explainers from the biocatalysis desk.
science
Physics-based framework targets high-throughput enzyme design
A bioRxiv preprint describes a physics-based framework that combines machine learning, molecular mechanics and microkinetic modelling to predict enzyme reaction rates and selectivity. In tests on an oxidative amidase, the authors report near-experimental accuracy across substrates, mutations and enzyme homologues.