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Khabre desk
Recent reporting, analysis and explainers from the biology desk.
science
A bioRxiv preprint analysing 231 haplotype-resolved human pangenomes reports that variable transposable elements can gain, change or lose regulatory effects before they become fixed. Their effects depend on DNA methylation and transcript context.
science
A bioRxiv preprint reports that RELAX produced different likelihood estimates in repeated runs, with some changes reversing statistical conclusions. The authors link the instability to site-class models and show that a seed alone did not ensure repeatable results in their tests.
science
A bioRxiv preprint reports metabolic changes and multiorgan pathology in ageing mice exposed to 450 nm LED light for 40 weeks.
science
Genetic ablation of the Unc13a cryptic exon preserved memory in a mouse model of TDP-43 dysfunction, supporting UNC13A as a therapeutic target for related dementias.
science
A bioRxiv preprint reports that the palm pest Rhynchophorus ferrugineus established on mainland America through Uruguay, spread across nearly 80,000 square kilometres and reached Argentina. The weevil is now attacking several native South American palms.
science
The US National Science Foundation plans to combine investigator-led research with agency-directed opportunities focused on four cross-disciplinary priorities. The agency has not yet specified the funding or allocation plan, raising concerns among staff about pressure on core discovery research.
science
A bioRxiv preprint reports that people in windowless offices exposed to desk lamps supplemented with 850-nm near-infrared light had reduced glucose measurements over a three-day experiment, while standard LED exposure was associated with increased levels. The study used an oral glucose tolerance test and continuous glucose monitoring.