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Khabre desk
Recent reporting, analysis and explainers from the biomanufacturing desk.
science
A bioRxiv preprint describes BRIDGE, a platform that transferred a 16-kilobase, five-gene violacein pathway into ten phylogenetically diverse yeast genera. Expression was strongest across six tested Saccharomyces species and varied in other yeasts.
science
A bioRxiv preprint reports valerolactam production in engineered Corynebacterium glutamicum, reaching 3.6 g/L after pathway design and fed-batch process optimization.
health
A medRxiv preprint identifies a possible manufacturing mechanism behind REP/CAP DNA sequences found in the liver of a patient treated with the rAAV gene therapy Zolgensma. The proposed mechanism involves the placement of the AAV P5 promoter in a manufacturing plasmid.