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Khabre desk
Recent reporting, analysis and explainers from the biomarkers desk.
health
A six-month pilot in 138 cognitively normal adults used family history, genetics and plasma pTau217 to identify people at higher Alzheimer’s risk. Participants who received personalised lifestyle coaching reported less worry, while cognitive scores and lifestyle-risk measures remained unchanged and pTau217 showed only a slower rise.
health
A medRxiv preprint analysed 344 postoperative drain-fluid samples from 67 pancreatic and colorectal surgery patients. It found that leakage was associated with different protein patterns over time in the two types of surgery.
science
A bioRxiv preprint reports that repeated measurements of circulating alanine aminotransferase, combined with time since acetaminophen exposure, estimated liver necrosis in mice. The method could let researchers follow liver injury in the same animals instead of using separate groups at every timepoint.
health
A medRxiv preprint used proteome-wide Mendelian randomization to identify 11 plasma proteins associated with early-onset stroke, defined as stroke occurring before age 60. The strongest signals involved coagulation and thromboinflammatory pathways, with Factor XI highlighted as a potential therapeutic target.
health
An international prospective study evaluated a blood assay that combines a 10-microRNA signature with carbohydrate antigen 19-9 for detecting early pancreatic ductal adenocarcinoma. The composite PANXEON score showed 86.8% sensitivity for stage I–II disease in the testing cohort, but the researchers say larger prospective studies are still needed.
health
A six-patient preprint found higher interferon-related gene scores in blood samples associated with dermatomyositis flares. The feasibility study used weekly at-home blood microsampling and RNA sequencing.
health
A Swedish case-control study found that a specific sugar-modified form of CA-125 was associated with ovarian cancer diagnosed several years later. The preprint suggests a possible early-risk signal, but larger studies using repeated samples are needed.
health
A medRxiv systematic review and meta-analysis found that the blood biomarker GFAP distinguished intracerebral hemorrhage from ischemic stroke, with pooled specificity of 87.2%. Accuracy was higher in samples taken within two hours, but sensitivity remained limited, particularly for smaller hemorrhages.
health
A medRxiv preprint reports that a risk score based on 28 gut microbial species was associated with cancer diagnoses during up to 10 years of follow-up. The finding comes from an observational analysis and represents a candidate biomarker for future validation, not a clinical screening test.