Search articles by title, topic or section.
Khabre desk
Recent reporting, analysis and explainers from the biophysics desk.
science
A bioRxiv preprint reports that centromeres in isolated human metaphase chromosomes have a distinct force response, including softening at some force levels. The researchers also found that topoisomerase IIα is recruited to centromeric regions under significant tension.
science
A bioRxiv preprint benchmarking differential scanning fluorimetry across 26 laboratories found good repeatability within instruments but moderate differences between them. The fluorescence readout and analysis workflow also affected apparent protein melting temperatures.
science
Researchers at King's College London report TomoFLIM, a compressed multiphoton fluorescence lifetime imaging method. In a preprint benchmark, it reproduced a 60-second raster-scanned dataset in 3.75 seconds.
science
A bioRxiv preprint reports that a metastable dimeric intermediate helps recombinant spidroin assemble into native-like fibrils in solution. X-ray diffraction showed that drying drives these fibrils toward amyloid-like cross-β structures.
science
A bioRxiv preprint reports that reinforcement learning identified previously unreported ways to initiate reentry in models of excitable tissue. Learned stimulation patterns produced unidirectional propagation in cardiac monolayers, while whole-heart experiments offered preliminary evidence that they can influence early wave propagation.
science
A bioRxiv preprint presents ForceFlowAb, a mixture-of-experts flow-matching model that designs antibody CDR sequences and structures with force-field guidance. The authors report more favourable antibody–antigen interaction-energy results than two comparison methods in CDR-H3 and six-CDR design tasks.
science
A bioRxiv preprint used giant unilamellar vesicles to visualise how two ionisable-lipid nanoparticles interact with model endosomal membranes. The results suggest that apparent pKa alone does not predict the pH at which functional membrane engagement occurs.