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Khabre desk
Recent reporting, analysis and explainers from the biophysics desk.
science
Researchers at King's College London report TomoFLIM, a compressed multiphoton fluorescence lifetime imaging method. In a preprint benchmark, it reproduced a 60-second raster-scanned dataset in 3.75 seconds.
science
A bioRxiv preprint reports that a metastable dimeric intermediate helps recombinant spidroin assemble into native-like fibrils in solution. X-ray diffraction showed that drying drives these fibrils toward amyloid-like cross-β structures.
science
A bioRxiv preprint reports that reinforcement learning identified previously unreported ways to initiate reentry in models of excitable tissue. Learned stimulation patterns produced unidirectional propagation in cardiac monolayers, while whole-heart experiments offered preliminary evidence that they can influence early wave propagation.
science
A bioRxiv preprint presents ForceFlowAb, a mixture-of-experts flow-matching model that designs antibody CDR sequences and structures with force-field guidance. The authors report more favourable antibody–antigen interaction-energy results than two comparison methods in CDR-H3 and six-CDR design tasks.
science
A bioRxiv preprint used giant unilamellar vesicles to visualise how two ionisable-lipid nanoparticles interact with model endosomal membranes. The results suggest that apparent pKa alone does not predict the pH at which functional membrane engagement occurs.