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Khabre desk
Recent reporting, analysis and explainers from the brain organoids desk.
science
A bioRxiv preprint presents a 658,059-cell reference atlas of human hippocampus development and uses it to study brain organoids carrying the familial Alzheimer’s disease-associated PSEN1 E280A variant. The organoids showed altered cell composition, gene expression and inferred neuronal maturation.
science
Researchers developed a mouse model in which human stem-cell-derived cortical organoids occupy most of the cerebral cortical space and connect with the host nervous system. The grafts showed organized electrical activity, influenced behaviour and produced measurable responses to experimentally induced hypoxic injury.
science
Nature reports extensive cellular integration after human brain tissue was transplanted into mice lacking a cortex. The work could provide a living-animal platform for testing therapies involving human neural tissue.