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Khabre desk
Recent reporting, analysis and explainers from the cancer-genomics desk.
health
A study of 62 pancreatic ductal adenocarcinomas found genetically distinct clones within tumours and linked MYC amplification to shifts between tumour cell states. Experiments in murine and primary human models showed that reducing MYC reactivated classical gene-expression and immune-response programs.
health
A longitudinal study linked routine clinical records from 52,236 adults with cancer to identify recurring episodes of significant weight loss. The episodes clustered around disease progression and were associated with consistent blood-marker changes and several tumor mutations.
health
A bioRxiv preprint reports four genomic subtypes of mucosal melanoma and immune-cell patterns associated with disease progression and immunotherapy resistance. The findings point to TIM-3 as a possible research target, not an established treatment.