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Khabre desk
Recent reporting, analysis and explainers from the cancer-research desk.
health
A single-nucleus atlas of colorectal tumours found a higher stromal-to-epithelial ratio in younger patients with microsatellite-stable cancer. The study also identified age-associated RNA signals and differences in computationally inferred cell communication.
science
A bioRxiv preprint maps nucleosome patterns across 410 tumours from 23 cancer types and reports that tissue-derived patterns could distinguish cancers using circulating cell-free DNA. The findings point to a possible source of information for non-invasive cancer detection, but the reported results are from research analyses rather than a demonstrated clinical test.
health
A bioRxiv preprint reports that reducing the catalytic activity of immunotoxin payloads improved selectivity between receptor-high and receptor-low cells. In an in vivo HER2-targeted test, the attenuated version had a 400-fold higher maximum tolerated dose than its wild-type counterpart.
health
A bioRxiv preprint links CXCR6-positive tissue-resident CD4 memory T cells with response to immune checkpoint inhibition in a glioma model. Analysis of patient tumour tissue also found an association with longer overall survival.
science
A bioRxiv preprint describes MCseg, a no-code tool whose segmentation workflow was selected through AI-agent-guided searches. In a lung adenocarcinoma dataset, its fixed-parameter workflow scored higher on panoptic quality than an Optuna-tuned Cellpose baseline.