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Khabre desk
Recent reporting, analysis and explainers from the cancer research desk.
science
Modern gene editing, high-resolution imaging and omics tools have expanded cell biology beyond the two classic forms of cell death. Researchers are also finding that some cells can delay death or recover after a death programme begins.
health
Nature Medicine has issued an Editorial Expression of Concern about a 2015 letter on EZH2 dependence in SWI/SNF-mutant cancers. The notice identifies similarities in several figure panels and says the original data are no longer available.
science
A bioRxiv preprint integrates genome-wide maps of DNA breaks, replication and transcription in U2-OS and HeLa cancer cell lines. It reports that prolonged low-dose DNA polymerase inhibition redirects breaks toward late-replicating regions and identifies MUS81 as a regulator of recurrent break clusters.
science
An investigation has found that drugs mimicking the effect of GABAergic neurons slowed glioma growth in mice. The result points to a possible way of targeting interactions between neurons and nervous-system cancer, but remains preclinical.
health
A medRxiv preprint reports that a risk score based on 28 gut microbial species was associated with cancer diagnoses during up to 10 years of follow-up. The finding comes from an observational analysis and represents a candidate biomarker for future validation, not a clinical screening test.