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BMJ Review Details Advances in Kidney Cancer Care

A BMJ clinical review describes how molecular classification, kidney-sparing treatment and immune-based combinations are shaping renal cell carcinoma care. It highlights improved outcomes in some settings alongside persistent resistance and a lack of validated biomarkers to guide treatment choice.

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Talazoparib Plus Enzalutamide Shows No Clear Extra Benefit in Prostate Cancer Trial

In a randomized phase 2 trial of 54 men with high-volume metastatic hormone-naive prostate cancer, talazoparib plus enzalutamide produced a high PSA response rate but no clear advantage over enzalutamide alone. Severe adverse events were more frequent with the combination, and two patients developed fatal acute myeloid leukaemia.