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Five-trial analysis finds lower pooled mortality with ATTR-CM treatments

A medRxiv preprint pooling five phase III trials reports lower all-cause mortality and better functional and health-status outcomes with disease-modifying treatments for transthyretin amyloid cardiomyopathy. Exploratory subgroup results found smaller effects on several non-mortality measures among patients taking a background stabilizer.

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Preprint Finds a Trade-Off Between Liwen Ablation and Myectomy in HCM

A single-centre retrospective preprint found that modified Morrow myectomy produced lower one-year LVOT gradients, while Liwen ablation was associated with fewer new conduction abnormalities and shorter procedures and hospital stays. The authors describe the findings as a trade-off requiring prospective confirmation.