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Khabre desk
Recent reporting, analysis and explainers from the cardiovascular-research desk.
health
A bioRxiv preprint reports that BCKDK inhibitors relax blood vessels by antagonising the angiotensin II type 1 receptor (AT1R), independently of BCKDK and branched-chain amino-acid breakdown. The experimental findings raise the possibility that some effects of these inhibitors arise from this separate receptor action.
health
A bioRxiv preprint reports that C3a receptor signalling in leptin-receptor neurons contributes to leptin resistance and obesity-related cardiac changes in mice. Human measurements of complement markers offer an associated finding, not evidence that targeting the pathway treats obesity in people.
health
A medRxiv preprint links ASXL1-mutant clonal haematopoiesis with aortic stenosis in human cohorts and reports enhanced calcification in a cultured-cell model. In laboratory experiments, blocking IL-1 or IL-6 reduced calcification.