science
DFCP1 Forms a Membrane Barrier That Organises Lysosome Repair Sites
A bioRxiv preprint reports that DFCP1 assembles into a helical coat that concentrates the membrane lipid PI3P and helps organise sites where cells repair damaged lysosomes.
Khabre desk
cell-biology
Recent reporting, analysis and explainers from the cell-biology desk.
science
Cell Painting PLUS adds organelle imaging to compound profiling
A bioRxiv preprint reports that Cell Painting PLUS uses additional organelle-resolved imaging to improve morphological profiling of compounds. In tests of 284 compounds in U2OS cells, it performed better than conventional Cell Painting for identifying compounds that interfere with lysosome function.
science
Biohub Expands Virtual Biology Initiative With $1.8 Billion Commitment
Biohub, US federal agencies and industry partners announced a combined $1.8 billion commitment to develop open, AI-ready biological data and measurement technologies. The initiative aims to support predictive models of cell behaviour; the announcement describes planned work, not a completed virtual cell.
science
Preprint maps a streamlined flagellar scaffold in malaria parasites
A bioRxiv preprint reports that Plasmodium male-gamete axonemes retain key surface motility modules but have a reduced set of proteins inside their microtubule doublets. It also describes proteins involved in doublet organization and the progressive assembly of outer dynein arms.