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PanChol booster study finds antibody seroconversion in 15 of 20 adults

In a phase 1a study of 20 healthy adults, 15 developed a fourfold rise in antibody titres against both cholera serotypes after a second PanChol dose. The preprint also reports reduced vaccine shedding after the booster, an indirect measure of intestinal immunity rather than a measure of protection from cholera illness.

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DRC Cholera Vaccination Campaign Estimated to Avert 56%

A surveillance-based modeling study estimates that a 2020 mass oral cholera vaccination campaign in Uvira, Democratic Republic of the Congo, averted 56% of infections and deaths over the following three years. The preprint estimates that 2,350 facility-attended cases and 44 facility and community deaths were prevented.