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Khabre desk
Recent reporting, analysis and explainers from the computational-biology desk.
science
A bioRxiv preprint introduces Chaperone, a framework for coordinating protein-design tools. Its authors report reduced token use and GPU costs across nine design tasks, alongside results from several protein-design campaigns.
science
Biohub, US federal agencies and industry partners announced a combined $1.8 billion commitment to develop open, AI-ready biological data and measurement technologies. The initiative aims to support predictive models of cell behaviour; the announcement describes planned work, not a completed virtual cell.
science
A bioRxiv preprint describes MIMOSA, a framework that guides antibody-generating models using the structure of a known binder interface. The authors report experimentally validated binders against three targets, with hit rates of 20–26%.
science
A bioRxiv preprint reports that targeted finetuning helped the co-folding model Boltz-1 predict a ligand-bound, inactive conformation of Werner helicase. The authors used ten previously unseen X-ray structures and report generalisation to other chemical series and related helicases.
science
A bioRxiv preprint uses Drosophila connectomics data and biophysical modeling to explain how visual neurons may distinguish a moving figure from whole-field background motion. The model centres on interactions between T4a motion neurons and vCH cells.
science
Apple researchers describe SimpleDesign, a Transformer-based model that jointly generates protein sequences and three-dimensional structures using a single-stage training approach. The system was trained on more than 2 million sequence–structure pairs, but the supplied evidence reports no experimental validation of its designs.
science
Google DeepMind says AlphaGenome Atlas pre-calculates predicted molecular effects for approximately 9 billion possible single-nucleotide changes, giving researchers a searchable tool for prioritising variants.