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Khabre desk
Recent reporting, analysis and explainers from the DNA methylation desk.
science
A bioRxiv preprint describes LongVerse, a system that uses AI agents to configure a fixed pipeline for haplotype-resolved DNA methylation analysis from Nanopore or PacBio reads. In tests on the HG002 reference genome, the authors report calls identical to a human expert’s and comparisons with bisulfite sequencing.
health
A medRxiv preprint reports five DNA-methylation clusters in 138 Wilms tumours and a classifier that identified WT1-driven tumours with about 90% accuracy. The researchers say using these patterns to guide genetic reanalysis uncovered previously unrecognised WT1 variants, including one that led to surveillance enrolment.
science
A bioRxiv preprint reports that UHRF1 reads ubiquitin marks it places on histone H3, promoting further marking and supporting DNA methylation maintenance in CpG-sparse regions.
health
A bioRxiv preprint reports that transplanted hearts rapidly assimilated recipients’ biological age in mouse experiments and patient analyses. The effect was detected in graft tissue, not as a change in the recipient’s systemic biological age.
science
A bioRxiv preprint reports that blood DNA methylation patterns vary across development, chronic disease and aging in humans and other mammals. The researchers also describe epigenetic clocks designed to predict expected mortality across species and tissues.