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ModDNA toolkit builds programmable DNA up to 100 kb

A bioRxiv preprint describes ModDNA, a sequence-design and cloning toolkit for building custom DNA molecules up to 100 kilobases. The researchers used the constructs in single-molecule visualisation assays, including an assay of DNA loop extrusion by human condensin I.

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Researchers report programmable spins built into DNA

A Technical University of Munich preprint describes synthetic DNA strands carrying flavin chromophores that generate spin-correlated radical pairs. The system can be manipulated with radiofrequency fields and read using optically detected magnetic resonance, with DNA sequence and structure controlling its response.