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Khabre desk
Recent reporting, analysis and explainers from the epigenetics desk.
science
A bioRxiv preprint maps nucleosome patterns across 410 tumours from 23 cancer types and reports that tissue-derived patterns could distinguish cancers using circulating cell-free DNA. The findings point to a possible source of information for non-invasive cancer detection, but the reported results are from research analyses rather than a demonstrated clinical test.
science
A bioRxiv preprint reports that UHRF1 reads ubiquitin marks it places on histone H3, promoting further marking and supporting DNA methylation maintenance in CpG-sparse regions.
health
A bioRxiv preprint reports that changes involving DNMT1 can reduce CTCF binding at the KMT2A gene and promote copy gains and rearrangements. The findings come from experimental molecular research, not a clinical study.
science
A bioRxiv preprint presents the first genome-wide maps of four major histone modifications in the reef-building coral Pocillopora damicornis. The maps associate distinct chromatin states with gene expression, receptor-related genes, developmental functions and transposable element-like regions.
science
A bioRxiv preprint reports that blood DNA methylation patterns vary across development, chronic disease and aging in humans and other mammals. The researchers also describe epigenetic clocks designed to predict expected mortality across species and tissues.
science
A bioRxiv preprint from Queen Mary University of London presents a genome-wide framework that uses native Oxford Nanopore reads to measure molecule-level DNA methylation variation and co-methylation. In human lymphoblastoid cell data, the analysis found patterns hidden by site-level averages.