Khabre branded placeholder image

science

EpiZoo model uses DNA sequence to compare single-cell epigenomics across species

A bioRxiv preprint introduces EpiZoo, a 2.6-billion-parameter model trained on about 20.9 million single cells from multiple species. Its authors report performance on several single-cell analysis tasks and describe applications in comparing regulatory patterns and prioritising cancer mutations.

Khabre branded placeholder image

science

AmbientMapper Targets Contamination in High-Throughput Single-Cell Data

A University of Michigan team has introduced AmbientMapper, a computational method that estimates ambient chromatin contamination in combinatorial single-cell experiments. In a bioRxiv preprint, the authors report a 0.19% wrong-genome rate on a 26-genome reference panel and recovery of low-depth nuclei that standard pipelines discarded.