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Khabre desk
Recent reporting, analysis and explainers from the gene editing desk.
science
A bioRxiv preprint uses electronic genome mapping to measure CRISPR-Cas9 target and off-target binding across the human genome in vitro. The study also examines how guide-RNA mismatches and binding-site spacing affect the system.
science
The European Union has changed how gene-edited crops are regulated, dividing them into NGT-1 and NGT-2 categories. The framework could ease adoption of CRISPR-based crop improvements, but limits on the number and size of edits may restrict more complex traits.
science
A bioRxiv preprint used giant unilamellar vesicles to visualise how two ionisable-lipid nanoparticles interact with model endosomal membranes. The results suggest that apparent pKa alone does not predict the pH at which functional membrane engagement occurs.