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Khabre desk
Recent reporting, analysis and explainers from the gene-expression desk.
science
A bioRxiv preprint analysing a PLP1-mutant Jimpy brain dataset finds that normalization choices and shared controls can affect which genes appear to move toward healthy levels after a rescue. The authors say such transcriptomic patterns can indicate broad state restoration without identifying which downstream gene mediates it.
health
A bioRxiv preprint reports gene-expression pathway changes after 24-hour drug exposures in human endometrial assembloids. The laboratory findings identify simvastatin and primaquine for further study, not as established endometriosis treatments.
science
A bioRxiv preprint reports that the bacterial protein RfaH helps Escherichia coli RNA polymerase continue through prolonged pauses during long-range transcription. In experiments using reconstituted transcription and in vivo depletion, RfaH supported longer transcription runs than NusG and was required for successful conjugation.