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Khabre desk
Recent reporting, analysis and explainers from the gene regulation desk.
science
A study of human and great-ape cartilage found roughly threefold lower glycosaminoglycan levels in humans and traced this difference to widespread changes in skeletal gene regulation. The authors suggest the shift may have influenced human skeletal traits and vulnerability to degenerative disease.
science
A bioRxiv preprint introduces SPECTRA, a graph-based model that predicts gene-expression responses to CRISPR perturbations by propagating signals through gene regulatory networks. The authors report improved recovery of sparse perturbation-related changes in a large-scale single-cell CRISPRi benchmark.
science
A Nature study in Arabidopsis maps how salicylic acid activates plant defence genes through NPR1 and relieves NPR3/NPR4-mediated repression. It identifies MED15A and chromatin changes that connect hormone perception to transcription.
science
A bioRxiv preprint presents the first genome-wide maps of four major histone modifications in the reef-building coral Pocillopora damicornis. The maps associate distinct chromatin states with gene expression, receptor-related genes, developmental functions and transposable element-like regions.