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Khabre desk
Recent reporting, analysis and explainers from the generative models desk.
science
A UCSF-led bioRxiv preprint introduces CELL-FM, a bidirectional generative model that connects protein sequences and cellular context with fluorescence microscopy images. The authors use it for virtual localization, motif analysis and mutagenesis of intrinsically disordered peptides.
science
A bioRxiv preprint presents ForceFlowAb, a mixture-of-experts flow-matching model that designs antibody CDR sequences and structures with force-field guidance. The authors report more favourable antibody–antigen interaction-energy results than two comparison methods in CDR-H3 and six-CDR design tasks.