science
Preprint describes click-chemistry method for modifying CRISPR complexes after assembly
A KU Leuven-led bioRxiv preprint describes a modular click-chemistry method for attaching fluorophores and DNA to CRISPR-Cas9 ribonucleoproteins without tying the engineering process to how the complex is assembled. In vitro experiments reported by the authors found that modifying an already formed complex provided two-fold greater accessibility of attached DNA.