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Khabre desk
Recent reporting, analysis and explainers from the genomic sequencing desk.
health
A medRxiv preprint identifies a possible manufacturing mechanism behind REP/CAP DNA sequences found in the liver of a patient treated with the rAAV gene therapy Zolgensma. The proposed mechanism involves the placement of the AAV P5 promoter in a manufacturing plasmid.
health
A medRxiv preprint reports a ligation-mediated PCR method that used long-read sequencing to resolve genomic contexts around four clinically relevant antibiotic-resistance genes in wastewater. Across 13 Washington state treatment plants sampled twice, the method found distinct context clusters, including 11 putatively novel qnrS-associated clusters.