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Khabre desk
Recent reporting, analysis and explainers from the glioma desk.
science
A bioRxiv preprint reports SPEAR, a method combining laser microdissection and mass spectrometry to measure RNA modifications in small regions of preserved tissue. In human diffuse glioma samples, the authors found lower levels of several methylated RNA modifications in higher-grade foci than in low-grade regions.
health
A bioRxiv preprint links CXCR6-positive tissue-resident CD4 memory T cells with response to immune checkpoint inhibition in a glioma model. Analysis of patient tumour tissue also found an association with longer overall survival.
science
An investigation has found that drugs mimicking the effect of GABAergic neurons slowed glioma growth in mice. The result points to a possible way of targeting interactions between neurons and nervous-system cancer, but remains preclinical.