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Human H1N1 strains repeatedly favoured α2,6-linked glycans

A bioRxiv preprint comparing human H1N1 strains collected from 1977 to 2024 reports a recurring preference for α2,6-sialylated glycans. The study also found changes in binding avidity and a binding-null egg-adapted mutant.

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Preprint proposes a more sensitive glycan analysis method

A University of Gothenburg preprint models glycan motifs as a containment hierarchy rather than independent features. Across 45 glycomics datasets, the authors report more estimated true positives and identify motif redistributions that conventional marginal analysis misses.