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Khabre desk
Recent reporting, analysis and explainers from the hippocampus desk.
science
A bioRxiv preprint reports that hippocampal Cajal-Retzius cells receive traced input from at least seven areas outside the hippocampus. The authors also describe strychnine-sensitive activity and close positioning of entorhinal fibres to glycinergic receptors.
science
A bioRxiv preprint reports that the timing of hippocampal neurons’ spikes relative to theta rhythms carried information about locations and viewed images, including in neurons without corresponding firing-rate changes. In human navigation data, spike timing improved location decoding beyond firing rates alone.
science
A bioRxiv preprint reports that seven days of partial sleep deprivation progressively reduced spontaneous neuronal activity in the live mouse hippocampus while tissue oxygen levels rose. After seven days of recovery, activity had not returned to baseline and oxygenation continued to increase.
science
A bioRxiv preprint comparing rats with Chinese tree shrews reports that tree-shrew CA1 uses a hybrid spatial code, combining weaker position tuning with more multiplexed neural activity. The findings suggest that spatial representations can change within a conserved hippocampal circuit while retaining core network properties.
science
A bioRxiv preprint combining mathematical modelling with intracellular recordings in behaving mice reports that CA3 pyramidal neurons have an activation exponent slightly above 1, as predicted for stable memory recall. The analysis included 49 new recordings and 133 cells from two earlier studies.
science
A bioRxiv preprint reports a single-neuron correlate of mnemonic pattern separation in the human hippocampus. The finding came from recordings of 3,506 neurons in 97 patients performing a recognition-memory task involving false memories.