Search articles by title, topic or section.
Khabre desk
Recent reporting, analysis and explainers from the immunotherapy desk.
health
A bioRxiv preprint reports that harmine plus exendin-4, given after low-dose anti-CD3 therapy, promoted remission in diabetic mice. Human cell experiments also showed effects on beta-cell function and immune responses.
health
A South Korean phase 1b/2 trial found a 55% objective response rate when trastuzumab and nivolumab were added to gemcitabine and cisplatin for previously untreated HER2-positive advanced biliary tract cancer. The single-arm results provide early evidence for first-line HER2-targeted chemoimmunotherapy, while randomized confirmation is still needed.
health
A bioRxiv preprint describes IL-2IT, a bispecific fusion protein designed to carry IL-2 to oxidation-specific epitopes at inflamed sites. In laboratory and in vivo models, the treatment showed greater Treg selectivity and benefits in psoriasis, colitis and atherosclerosis models.
health
A retrospective study of 2,396 people with advanced NSCLC found clinical-data AI models outperformed single biomarkers and helped physicians predict treatment response and survival.