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Khabre desk
Recent reporting, analysis and explainers from the infectious-disease desk.
science
A bioRxiv preprint reports that lysosomal acid lipase helps release cholesterol during phagosome maturation. Inhibiting the enzyme changed membrane organisation and had different effects on the survival of two bacterial pathogens.
health
A prospective observational study at two tertiary-care hospitals found that broad whole-genome sequencing detected many Gram-negative genomic clusters involving patients without multidrug-resistant isolates or intensive-care exposure. The medRxiv preprint also found that detection increased with sequencing effort and that blood-culture-only surveillance would have identified very few clustered patients.