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Khabre desk
Recent reporting, analysis and explainers from the inflammation desk.
science
A bioRxiv preprint identifies the nuclear enzyme MSK1 as a regulator of TRPV1 expression in a specific subset of pain-sensing neurons. In experimental models, blocking this inflammatory pathway reduced heat hypersensitivity while preserving acute heat sensation and body-temperature control.
science
A bioRxiv preprint reports that blocking the P2Y6 receptor reduced CCL2 but increased CXCL1 release from mouse macrophages stimulated through TLR3. The findings identify extracellular-nucleotide signaling as a selective regulator of inflammatory chemokine responses in this cell model.
health
A bioRxiv preprint describes IL-2IT, a bispecific fusion protein designed to carry IL-2 to oxidation-specific epitopes at inflamed sites. In laboratory and in vivo models, the treatment showed greater Treg selectivity and benefits in psoriasis, colitis and atherosclerosis models.