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Single-amplicon method sequences rhinovirus and enterovirus genomes

A bioRxiv preprint describes a single-amplicon sequencing workflow that recovered high-quality rhinovirus genomes from clinical specimens and enterovirus coding sequences from isolates. The authors report lower reagent costs and shorter processing time than hybridization capture sequencing.

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Multi-lab Study Finds DSF Protein Stability Readings Vary

A bioRxiv preprint benchmarking differential scanning fluorimetry across 26 laboratories found good repeatability within instruments but moderate differences between them. The fluorescence readout and analysis workflow also affected apparent protein melting temperatures.