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Blood test combining microRNAs and CA19-9 shows potential for early pancreatic cancer detection

An international prospective study evaluated a blood assay that combines a 10-microRNA signature with carbohydrate antigen 19-9 for detecting early pancreatic ductal adenocarcinoma. The composite PANXEON score showed 86.8% sensitivity for stage I–II disease in the testing cohort, but the researchers say larger prospective studies are still needed.

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Blood cfDNA matched marrow signals in multiple myeloma study

A medRxiv preprint compared matched blood and bone-marrow cell-free DNA from 74 people with multiple myeloma. Peripheral-blood cfDNA matched or exceeded marrow-plasma cfDNA for several genomic signals, while fragment patterns varied by sample compartment and handling.