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Khabre desk
Recent reporting, analysis and explainers from the liquid-biopsy desk.
health
A Nature Medicine study reports that urine cell-free RNA sequencing detected localized bladder cancer with 95% sensitivity at 90% specificity. The researchers also investigated its potential for detecting residual disease and predicting response to bladder treatments.
science
A bioRxiv preprint reports that tumour-cell states, mutations, tumour architecture and immune signals were associated with differences in ctDNA release in ten patients with non-metastatic HR+/HER2− breast cancer. The findings offer a biological framework for understanding why tumour DNA detected in tissue may differ from what appears in blood.
health
A bioRxiv preprint reports that plasma mass spectrometry could detect some tumor-associated peptides, but neoepitope searches were constrained by limited overlap between cfDNA and tumor mutations and by MS sensitivity. Tissue remained the stronger reference for identifying tumor mutations and neoepitopes.