science
DFCP1 Forms a Membrane Barrier That Organises Lysosome Repair Sites
A bioRxiv preprint reports that DFCP1 assembles into a helical coat that concentrates the membrane lipid PI3P and helps organise sites where cells repair damaged lysosomes.
Khabre desk
lysosomes
Recent reporting, analysis and explainers from the lysosomes desk.
science
STARD9 variants linked to opposite lysosome positioning
A bioRxiv preprint reports that rare and common STARD9 variants are associated with different lipid disorders and opposite changes in lysosome positioning. The authors connect those differences to cholesterol handling in cells and, in knockout mice, to intestinal cholesterol absorption.