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health

Prostate micro-ultrasound AI model improves analysis with fewer labels

A medRxiv preprint reports that muFM, a model pretrained on more than 1.7 million unlabeled micro-ultrasound images, improved performance on three prostate image-analysis tasks. Gains were largest when the model was fine-tuned with limited annotated data.

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science

Preprint reports natural enzymes for a key FDCA production step

A bioRxiv preprint describes four rounds of computational screening that identified natural hydroxymethylfurfural oxidases with improved activity on a key FDCA-production reaction. Some candidates approached an engineered benchmark under the tested conditions.

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science

A Model Uses ACE2 Sequences to Predict SARS-CoV-2 Host Range

A bioRxiv preprint describes a transformer model trained on 8.8 million measured SARS-CoV-2 RBD–ACE2 interactions. It predicts receptor-binding compatibility across animal species and pairs predictions with uncertainty estimates to help prioritise surveillance.

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science

Protein-affinity benchmark finds deep-learning models vary across targets

A bioRxiv preprint introduces PLABench, a benchmark comparing nine deep-learning methods for predicting protein–ligand binding affinity. Its authors report that strong overall accuracy did not translate into consistent performance across targets or protein families.

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science

Deep learning maps how temperature affects Douglas-fir pollen

A bioRxiv preprint describes a convolutional neural network that measured Douglas-fir pollen germination and elongation across temperatures from 5 to 40°C. The study found narrow, distinct thermal optima for the two reproductive processes, mostly between 19 and 23°C.