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Blood protein study links menopause biology to brain aging and dementia risk

A Nature Medicine study identified menopause-related blood protein patterns associated with hormonal changes, brain aging and less favourable cognitive outcomes later in life. The observational findings provide a research framework for studying how the menopause transition may intersect with dementia risk.

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Menopause Therapy’s Brain Associations Vary by Formulation and APOE ε4

A medRxiv preprint analysing 8,741 female participants older than 70 reports that associations between menopause hormone therapy, cognition and brain structure differed by treatment formulation and APOE ε4 status. Among APOE ε4 carriers, estradiol-based therapy was linked to more favourable cognitive and imaging measures than conjugated equine estrogens.