science
MERS-CoV Spike Mutations Resist Soluble DPP4 in Cell Experiments
A bioRxiv preprint reports that MERS-CoV spike substitutions L507I and L507H reduced binding to soluble DPP4 while preserving entry into cells with high DPP4 levels. Polymorphisms at the same site found in patient virus sequences showed stronger resistance in the study’s VSV-based cell system.