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Khabre desk
Recent reporting, analysis and explainers from the meta-analysis desk.
health
A medRxiv preprint pooling five phase III trials reports lower all-cause mortality and better functional and health-status outcomes with disease-modifying treatments for transthyretin amyloid cardiomyopathy. Exploratory subgroup results found smaller effects on several non-mortality measures among patients taking a background stabilizer.
health
A preprint meta-analysis of 14 observational studies found that preoperative anaemia was associated with higher odds of transfusion, kidney complications, early mortality and infection after adult cardiac surgery. The authors report low or very low certainty for these findings and say the observational evidence cannot establish causation.
health
A medRxiv preprint meta-analysis of 11 studies found that higher continuous glucose monitoring time in range was associated with lower odds of diabetic kidney disease. Most included studies were cross-sectional, so the findings do not establish cause and effect.