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Khabre desk
Recent reporting, analysis and explainers from the metabolism desk.
health
A Nature Medicine review describes why people with obesity can differ in insulin sensitivity and related metabolic measures. It also examines how metabolic responses to weight reduction vary.
science
A bioRxiv preprint maps labeled nutrients across adult female fruit flies, finding distinct patterns of metabolism in different body regions. In flies with gut tumors, alanine’s contribution to malate increased, and reducing gut alanine uptake lowered tumor burden.
health
A bioRxiv preprint reports that age-related bone loss in mice coincided with impaired glycolysis in bone tissue. Caloric restriction and osteoblast-specific genetic interventions that enhanced glycolysis improved bone outcomes in the mice.
science
A bioRxiv preprint reports that BXD34 mice resisted diet-induced obesity and insulin resistance despite eating more, alongside widespread urinary nutrient loss. The strain was also profoundly susceptible to acute kidney injury.
science
A bioRxiv preprint reports that people in windowless offices exposed to desk lamps supplemented with 850-nm near-infrared light had reduced glucose measurements over a three-day experiment, while standard LED exposure was associated with increased levels. The study used an oral glucose tolerance test and continuous glucose monitoring.