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Shotgun sequencing detects three Leptospira species in Philippine samples

A medRxiv preprint reports that shotgun metagenomic sequencing identified Leptospira genetic material and provided species-level assignments in archived samples from suspected Philippine leptospirosis cases. The method detected pathogenic Leptospira in 60% of qPCR-positive samples that were negative by the microscopic agglutination test.

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Preprint study finds anaerobic microbiome signature in anal cancer

A prospective medRxiv study of 121 adults found six anaerobic species enriched in anal squamous cell carcinoma compared with high-grade lesions. The microbial pattern persisted during follow-up and changed after treatment initiation.