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Khabre desk
Recent reporting, analysis and explainers from the metagenomics desk.
science
A bioRxiv preprint reports that simulated mixtures of E. coli strains made sequence-type and serotype prediction less reliable than detection of individual resistance and virulence genes. Increasing the dominant strain’s abundance improved strain-level predictions, while longer reads alone did not resolve the challenge.
science
A bioRxiv preprint describes DeepMM, a method that detects suspected misassembly junctions and splits contigs before microbial genomes are grouped into bins. In benchmark datasets, this reduced gene annotations that disagreed with sample-matched reference genomes.
science
An Anthropic-authored bioRxiv preprint reports that Claude Code agents surveyed 1.9 billion protein clusters and identified a family of phage reverse transcriptases associated with tandem DNA repeats. The researchers also report that the repeat arrays are highly expressed during Staphylococcus phage infection.