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Khabre desk
Recent reporting, analysis and explainers from the microbiome desk.
health
A six-month study of 356 perimenopausal women in China found that microbiome changes during hormone therapy differed by body site. Microbial patterns present before treatment were associated with differences in hormonal and symptom responses.
health
A small phase 1b trial reported fewer bloodstream infections among donor stem-cell transplant recipients given SER-155 with vancomycin conditioning than among placebo recipients. The result is an early clinical signal from a small group, and the tested regimen combined both treatments.
health
A bioRxiv preprint reports that a defined consortium of four enteric microbes gave laboratory mice several immune features seen in pet-store mice and adults. The authors also report changes in tumour patterns and CAR T-cell responses in mouse models.
science
A bioRxiv preprint analysing about 29,000 microbiomes reports that network and functional traits were associated with community stability under drought, warming and salinity. The authors suggest baseline sequencing could help identify vulnerable communities before disturbance.
health
A medRxiv preprint found that Staphylococcus dominance in endotracheal aspirates was associated with worse 60-day survival among mechanically ventilated patients with culture-confirmed Staphylococcus aureus pneumonia. Sequencing also linked higher bacterial burden to mortality.
health
A prospective medRxiv study of 121 adults found six anaerobic species enriched in anal squamous cell carcinoma compared with high-grade lesions. The microbial pattern persisted during follow-up and changed after treatment initiation.