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Khabre desk
Recent reporting, analysis and explainers from the mitochondria desk.
health
A bioRxiv preprint reports that TFAM-insufficient CD8⁺ T cells in influenza-infected mice were associated with lung immunopathology and weaker later immune responses, without improved viral control. The researchers also observed age-associated declines in TFAM expression and mitochondrial function in human CD8⁺ T cells.
science
A bioRxiv preprint uses single-cell transcriptomics to reconstruct an unusual anaerobic mitochondrion in the rhizarian flagellate PCE SSF. The proposed metabolism includes hydrogen production and a reduced, branched pathway for processing carbon.
science
A bioRxiv preprint reports that mitochondrial DNA mutations arising during mice’s first two months were sufficient to drive age-related pathologies. The authors also found that tissue-specific selection and mitochondrial fusion influenced the mutations’ later fate.
health
A bioRxiv preprint links the mitochondrial protein OPA1 to liver fibrosis through human MASLD analyses and experiments in mice. The mouse findings connect loss of OPA1 in liver cells with stellate-cell activation and fibrosis.
health
A bioRxiv preprint links neutrophil alpha-defensins to mitochondrial changes and fat accumulation in liver cells. The proposed pathway is supported by cell experiments and a mouse model, while the patient findings are correlational.