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RfaH helps bacterial RNA polymerase sustain long-range transcription

A bioRxiv preprint reports that the bacterial protein RfaH helps Escherichia coli RNA polymerase continue through prolonged pauses during long-range transcription. In experiments using reconstituted transcription and in vivo depletion, RfaH supported longer transcription runs than NusG and was required for successful conjugation.

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Study finds human protein variants beyond genetic sequence

A Nature study analysed a large-scale proteogenomic dataset from 29 healthy human tissues and identified 13,910 protein variants, including non-genetic amino-acid substitutions. The findings suggest that errors and variation during protein production may expand the set of protein forms with potential biological functions.