Search articles by title, topic or section.
Khabre desk
Recent reporting, analysis and explainers from the neuroinflammation desk.
science
A bioRxiv preprint reports cryo-EM structures of human THIK1 bound to two chemically related inhibitors. Both occupy the same pore site, but structural and electrophysiological results indicate that they affect a second channel gate differently.
science
A bioRxiv preprint reports that the accessibility and membrane organisation of cholesterol help control TLR4 signalling in microglia. The study identifies SR-B1 and sphingomyelin–cholesterol interactions as regulators of this inflammatory pathway.
health
A medRxiv preprint reports that laromestrocel reduced measures of brain inflammation and atrophy in 49 people with mild Alzheimer’s disease. The findings come from an early clinical study and have not yet been published as a peer-reviewed journal article.